This paper studies the application of centralized cloud predictive control based on dSPACE system in multiple lighting system control. A centralized cloud predictive control scheme is designed to achieve the consistency and stability of multiple lighting controls at the same time. The dSPACE multiple lighting control system is corrected and modeled. The design of a cloud prediction controller based on the dSPACE system is introduced in detail. The cloud predictive control scheme is analyzed through simulation experiments, and the effective parameters of stability and consistency of closed-loop multiple lighting control systems are given. The effectiveness of the proposed scheme on the dynamic behavior and control performance of multiple lighting systems is verified. The research results provide a foundation for multiple lighting cooperative control and its application. Finally, the stability and consistency of the controller are verified by the physical experiment platform based on DSPACE.